Haploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable.\nHistorically, the decision of considering haploidentical transplant has remained elusive; however, with the recent\nadvances, the consideration of haploidentical grafts as a treatment option has become more apparent for both allografting for\ndiseases and engraftment failure. We are reporting here an anecdotal case of a successful haploidentical engraftment in a patient\nwith the prior graft failure of an HLA-matched related donor. Since the patient was severely alloimmunized, desensitization\nprotocol was utilized before the haploidentical transplant, and the patient after 8 months of her second allogeneic transplantation\nis doing great with successful engraftment, no relapse, and no graft-versus-host disease (GVHD). Numerous reports pertinent to\nhaploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in\nthe morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more\nfeasible and has meaningful implications in the situations where matched donors are infrequent.
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